GENETICS 133 — GENETICS IN THE NEWS

3 credits.

The science of genetics is at the heart of many issues facing our society, and as such, genetics is often in the news. Explores the underlying genetics and methodologies to gain a deeper understanding of the science behind the headlines so that we can make more informed decisions as citizens. Enroll Info: None

GENETICS 155 — FRESHMAN SEMINAR IN GENETICS

1 credit.

Introduction to the discipline of genetics, to the UW Laboratory of Genetics, to some of the research projects the faculty are pursuing, to resources available at UW-Madison, and to the career options open to an individual with a genetics undergraduate degree. Enroll Info: None

GENETICS 289 — HONORS INDEPENDENT STUDY

1-2 credits.

Research work for Honors students under direct guidance of a faculty member in an area encompassing Genetics. Students are responsible for arranging the work and credits with the supervising instructor. Enroll Info: None

GENETICS 299 — INDEPENDENT STUDY

1-3 credits.

Research work for students under direct guidance of a faculty member in an area encompassing Genetics. Students are responsible for arranging the work and credits with the supervising instructor. Enroll Info: None

GENETICS 375 — SPECIAL TOPICS

1-4 credits.

Specialized subject matter of current interest to undergraduate students. Enroll Info: None

GENETICS 399 — COORDINATIVE INTERNSHIP/COOPERATIVE EDUCATION

1-8 credits.

An internship under guidance of a faculty or instructional academic staff member in Genetics and internship site supervisor. Students are responsible for arranging the work and credits with the faculty or instructional academic staff member and the internship site supervisor. Enroll Info: None

GENETICS 400 — STUDY ABROAD IN GENETICS

1-6 credits.

Provides an area equivalency for courses taken on Madison Study Abroad Programs that do not equate to existing UW courses. Enroll Info: None

GENETICS 466 — PRINCIPLES OF GENETICS

3 credits.

Genetics in eukaryotes and prokaryotes. Includes transmission genetics, molecular genetics, evolutionary genetics, genetic engineering, and societal issues associated with genetics. Illustrative material includes bacteria, plants, insects, and vertebrates. Enroll Info: None

GENETICS 467 — GENERAL GENETICS 1

3 credits.

Genetics of eukaryotes and prokaryotes. Includes Mendelian genetics, probability and hypothesis testing, genetic mapping, molecular genetics, gene expression and genetic engineering. Illustrative material includes viruses, bacteria, plants, fungi, insects, and humans. Enroll Info: None

GENETICS 468 — GENERAL GENETICS 2

3 credits.

Genetic analysis, population genetics, evolution and quantitative genetics. Includes mutant screens, pathway analysis, mosaic analysis, reverse genetics, genomics, Hardy-Weinberg linkage equilibrium, inbreeding, genetic drift, natural selection, population structure, inheritance of complex traits, domestication and human evolution. Enroll Info: None

GENETICS 470 — BASIC CYTOLOGY AND LABORATORY PROCEDURES

1 credit.

A comprehensive review of cellular biology, the study of optical methods with emphasis on the light microscope and the various techniques used in preparation and staining of specimens for cytologic and histologic study. Enroll Info: None

GENETICS 471 — ADVANCED LABORATORY PROCEDURES

1 credit.

Preparation of non-gynecologic cytologic specimens using several different instrument methodologies. Application of universal precautions and safety in the handling of unknown biologic hazards. Introduction to histologic preparatory techniques and special staining methods. Enroll Info: None

GENETICS 520 — NEUROGENETICS

3 credits.

The genetic basis of nervous system development, structure, function, and dysfunction. Will emphasize both current research findings on the genetic basis of specific neurological disorders, as well as genetic methodologies and experimental approaches used in neurobiological research. Enroll Info: None

GENETICS/​BIOLOGY  522 — EVOLUTION SEMINAR SERIES-UNDERGRADUATE

1 credit.

The Evolution Seminar Series exposes students to diverse topics in contemporary evolutionary biology. Most weeks, one or more guest lecturers present their own primary research on a specialized topic in evolutionary biology. Diverse seminars include perspectives from genetics, ecology, geoscience, zoology, botany, microbiology, systematics, molecular biology, and integrative research. Some weeks feature special topics and discussions on pedagogical, legal, outreach, or other issues in evolutionary biology. Students learn to think critically about methodology, experimental design and interpretation, and how conclusions are reached in evolutionary biology by reading primary and secondary literature, attending seminars, discussing topics with speakers and other students, moderating discussions, and preparing a written report. Enroll Info: Prior or concurrent enrollment in ZOOLOGY/​ANTHRO/​BOTANY  410

GENETICS 525 — EPIGENETICS

3 credits.

Introductory course in epigenetics - the layer of chemical information that sits on top of the genome - that switch genes 'on' or 'off'. Will introduce how the epigenome, in collaboration with the genome, controls versatile biological processes and cell fates. Will also cover the latest advances of how humans can control their own epigenetic destiny by lifestyle, diet, and other environmental factors. Enroll Info: None

GENETICS 527 — DEVELOPMENTAL GENETICS FOR CONSERVATION AND REGENERATION

3 credits.

Human-induced factors such as changes in land use and global climate are causing rapid worldwide biodiversity loss. Can modern molecular genetics contribute to species preservation? In this course, we will first explore the challenges and potential of molecular genetic methods based on biobanking, gene editing and nuclear transfer for animal biodiversity preservation. Topics covered will include: i) maternal factors and early animal development, ii) interspecies somatic cell nuclear transfer (isSCNT) and oocyte-mediated reprogramming in animal cloning, iii) developmental, phylogenetic and ecological considerations for biobanking, iv) gene editing and synthetic biology as potential tools to recapture biodiversity. Use knowledge in animal population status, developmental genetics and phylogeny to address real-life problems involving the conservation of threatened animal populations. Enroll Info: None

GENETICS 528 — BANKING ANIMAL BIODIVERSITY: INTERNATIONAL FIELD STUDY IN COSTA RICA

1 credit.

Study abroad course that provides an on-site educational experience where we use developmental genetics concepts to guide projects of biobanking and oocyte-mediated cloning, as a potential last-defense resort for the preservation of living species under risk of extinction. It will provide hands-on experience in current research and activities in biodiversity areas, including visits to biodiversity-rich ecosystems, on site seminars and demonstrations, biodiversity preservation activities, as well as exposure to local culture and social needs. Enroll Info: None

GENETICS 545 — GENETICS LABORATORY

2 credits.

Gain practical experience in classical and molecular genetic laboratory techniques using plants, animals, and fungi. Topics include complementation and linkage analysis, gene mapping, library screening, yeast and bacterial transformation, restriction analysis, PCR, sequencing, and Southern blot analysis. Enroll Info: None

GENETICS 548 — THE GENOMIC REVOLUTION

3 credits.

Profound advances are now possible thanks to genomic data and analysis. Introduces the structure, function, and evolution of genomes. It also outlines the realized and prospective benefits of genomic technology for human health, agriculture, and conservation. Enroll Info: None

GENETICS/​HORT  550 — MOLECULAR APPROACHES FOR POTENTIAL CROP IMPROVEMENT

3 credits.

Introduction of basic concepts of plant molecular biology and molecular techniques in current use. Topics include: organization and regulation of plant genes, gene cloning and analysis, transformation systems for plants, and molecular techniques for crop improvement. Enroll Info: None

GENETICS/​MD GENET/​ZOOLOGY  562 — HUMAN CYTOGENETICS

2 credits.

Fundamental principles of cytogenetics and special problems of human cytogenetics. Enroll Info: None

GENETICS 564 — GENOMICS AND PROTEOMICS

3 credits.

The basic principles of genomics, proteomics and bioinformatics will be taught through a semester-long project of the students choosing. Creative problem solving in science skills will be learned through a variety of active-learning techniques that include: reading of primary literature, group presentations, peer review, bioinformatic lab exercises, science communication skills (writing visualization), and creating a website. Emphasis will be placed upon how to effectively communicate science (written, oral and written). Topics include: genomic sequencing, phylogeny, domain analysis, transcriptomics, CRISPR screens, chemical genomics, quantitative proteomics and protein networks. Capstone course. Enroll Info: None

GENETICS/​MD GENET  565 — HUMAN GENETICS

3 credits.

Principles, problems, and methods of human genetics. Surveys aspects of medical genetics, biochemical genetics, molecular genetics, cytogenetics, quantitative genetics, and variation as applied to humans. Enroll Info: None

GENETICS 566 — ADVANCED GENETICS

3 credits.

Principles of classical and modern genetic analysis taught through readings in the scientific literature and group projects. Capstone course. Enroll Info: None

GENETICS 567 — COMPANION RESEARCH SEMINAR

1 credit.

Student-led discussions on scientific, societal, and professional topics relevant to Senior research and selected original research presentations. Enroll Info: None

GENETICS 568 — THE CENTRAL NERVOUS SYSTEM

1 credit.

Anatomy, physiology, histology and pathology of the central nervous system and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen preparation. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. Enroll Info: None

GENETICS 569 — THE BREAST

1 credit.

Anatomy, histology, physiology and pathology of the breast and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of the didactic information with the microscopic cell patterns to provide a diagnosis. Enroll Info: None

GENETICS 570 — THE FEMALE REPRODUCTIVE SYSTEM

8 credits.

Anatomy, histology, physiology, and pathology of the female reproductive tract and the corresponding cellular manifestations which provide diagnostic information. Cellular changes due to therapy and specimen collection. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. Enroll Info: None

GENETICS 571 — CLINICAL PRACTICE I

1 credit.

Clinical practicum to develop diagnostic expertise involving the microscopic examination of routine gynecologic specimens (Pap smears). Observe the signout of abnormal cytologic specimens by cytopathologist staff. Enroll Info: None

GENETICS 572 — THE RESPIRATORY SYSTEM

3 credits.

Anatomy, histology, physiology and pathology of the respiratory tract and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. Enroll Info: None

GENETICS 573 — THE GENITOURINARY SYSTEM

2 credits.

Anatomy, physiology, histology and pathology of the urinary tract and male reproductive systems and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of didactic information with microscopic cell patterns to provide a diagnosis. Enroll Info: None

GENETICS 574 — THE GASTROINTESTINAL SYSTEM

3 credits.

Anatomy, histology, physiology and pathology of the gastrointestinal system and the corresponding cellular manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. Enroll Info: None

GENETICS 575 — MISCELLANEOUS SYSTEMS

3 credits.

Anatomy, histology, physiology and pathology of skin, thyroid, lymph nodes and other sites and the corresponding celluular manifestations which provide diagnostic information. Emphasis on specimen collection by fine needle aspiration. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. Enroll Info: None

GENETICS 576 — EFFUSIONS

2 credits.

Anatomy, physiology, histology and pathology of the body cavities. Cytologic manifestations which provide diagnostic information. Cell changes related to specimen processing. Correlation of the didactic information with the microscopic cellular patterns to provide a diagnosis. Enroll Info: None

GENETICS 577 — APPLIED CYTOLOGY I

1 credit.

Written and practical application of the comprehensive body of knowledge to all aspects of preparation, evaluation, correlation and diagnosis of cytologic speciments. Enroll Info: None

GENETICS 578 — APPLIED CYTOLOGY II

1 credit.

Written and practical application of the advanced comprehensive body of knowledge to all aspects of preparation, evaluation, correlation and diagnosis of cytologic specimens. Practice in nationally offered cytologic examinations. Enroll Info: None

GENETICS/​BIOCHEM/​MICROBIO  612 — PROKARYOTIC MOLECULAR BIOLOGY

3 credits.

Molecular basis of bacterial physiology and genetics with emphasis on molecular mechanisms; topics include nucleic acid-protein interactions, transcription, translation, replication, recombination, regulation of gene expression. Enroll Info: None

GENETICS/​AGRONOMY/​AN SCI/​HORT  615 — GENETIC MAPPING

3 credits.

Computing-intensive course to prepare students for genetic mapping research; linkage analysis and QTL mapping in designed crosses; linkage disequilibrium and association analysis (GWAS). Enroll Info: Recommended preparation is undergraduate courses in genetics and statistics and prior experience writing R scripts (such as module 1 of STAT 327).

GENETICS/​BIOCHEM/​MD GENET  620 — EUKARYOTIC MOLECULAR BIOLOGY

3 credits.

Focuses on the basic molecular mechanisms that regulate DNA, RNA, and protein metabolism in eukaryotic organisms. Enroll Info: None

GENETICS/​ENTOM/​ZOOLOGY  624 — MOLECULAR ECOLOGY

3 credits.

Basic principles of molecular ecology. Lecture topics include population genetics, molecular phylogenetics, rates and patterns of evolution, genome evolution, and molecular ecology. Enroll Info: None

GENETICS/​CHEM  626 — GENOMIC SCIENCE

2 credits.

This course is designed to bring cutting-edge topics in the genomic sciences into the reach of traditionally "pure" chemistry, biology, engineering, computer science statistics students. It is also designed for enabling biologically-oriented students to deal with the advances in analytical science so that they may incorporate new genomic science concepts into their own scientific repertoires. Intended for graduate students and for undergraduates with extensive research experience. Enroll Info: None

GENETICS 627 — ANIMAL DEVELOPMENTAL GENETICS

3 credits.

Advanced genetics course focusing on genetic mechanisms of animal embryonic development, with particular emphasis on central molecular circuitries that control development and genetic analytical tools used to reveal them. Address topics including maternal and epigenetic inheritance, the egg-to-embryo transition, pattern formation, organogenesis, coordination of cellular and molecular mechanisms, and animal models of human congenital disorders. Enroll Info: None

GENETICS 631 — PLANT GENETICS

2 credits.

Covers the basic concepts of genetics and genomics as applied to plants, including discussions on breeding systems (modes of reproduction, sex determination, self incompatibility and crossing barriers), linkage analysis, genome structure and function (structure, function and evolution of nuclear and organellar chromosomes; haploidy and polyploidy; expression regulation and epigenetics), and a description of current methodologies used in the analysis of these processes. Our objective is to instigate in students a broader knowledge and understanding of the principles and methodologies used in plant genetics such that they can adopt them most effectively in their own research projects, and can describe and discuss them more thoroughly with the general public. Enroll Info: None

GENETICS 633 — POPULATION GENETICS

3 credits.

Population genetics, aimed at preparing students to initiate research in this field. Explore how genetic variation is influenced by mutation and recombination, population size changes and migration, and natural selection for or against new mutations. Enroll Info: None

GENETICS/​BOTANY/​M M & I/​PL PATH  655 — BIOLOGY AND GENETICS OF FUNGI

3 credits.

Fungal genetics, genomics, and physiology using plant pathogenic fungi and the genetic models Aspergillus nidulans and Neurospora crassa as model systems to explore the current knowledge of fungal genetics and plant/fungal interactions. Enrollment open to graduate students, but undergraduates welcome to contact instructor for permission. All students should have some prior coursework in genetics (such as GENETICS 466 or 467) and microbiology (such as MICROBIO 303). It is also recommended that students take PL PATH 300 332 prior to this course. Enroll Info: Graduate or professional standing

GENETICS 660 — EVOLUTIONARY GENOMICS

2 credits.

We will present and discuss modern topics in evolutionary genomics, including genomic approaches, their application to evolutionary biology, and insights gleaned from such studies. Topics include evolution of genome architecture, gene content, and sequences. The course also covers molecular evolution as applied to the genome scale. Enroll Info: GENETICS 466 or Biocore 301/302 sequence or equivalent, and consent of instructor

GENETICS/​MD GENET  662 — CANCER GENETICS

3 credits.

Cancer remains one of the most difficult health issues facing our society. There is hope in the horizon due to an increasing understanding of both genetic and epigenetic alterations in cancer. In particular, DNA sequencing of human cancers is becoming more common in major health care centers, and there is expectation that this technology will allow for personalized medicine. Thus, there has been a rapid increase in this knowledge over the last decade. Become aware of the current major issues in cancer research and critically evaluate the cancer genetics literature. Enroll Info: None

GENETICS 670 — SEMINAR IN CLINICAL CYTOGENETICS

1 credit.

Overview of the basic features of chromosome structure and behavior including karyotyping clinical correlates of numerical and structural chromosome aberrations, sex chromosome abnormalities, breakage syndromes and the chromosomal changes associated with the development of cancer. Enroll Info: None

GENETICS 671 — ADVANCED CLINICAL PRACTICE

8 credits.

Clinical practicum to develop diagnostic expertise of cytologic specimens. Examine challenging cases with emphasis on diagnostic pitfalls. Observe patient clinics related to cytologic specimen collection. Participate at clinical experiences in fine needle aspiration, histology, and a private cytology laboratory. Enroll Info: None

GENETICS 672 — SEMINAR IN LABORATORY OPERATIONS AND QUALITY CONTROL

1 credit.

Review the fundamentals of basic administrative functions and regulatory requirements including planning, organizing, supervising and controlling business management, record keeping, data processing and laboratory safety. Quality assurance procedures necessary for obtaining, processing, diagnosing and reporting cytologic specimens. Enroll Info: None

GENETICS 673 — SEMINAR IN CLINICAL CYTOLOGY

1 credit.

Preparation of a case study or clinical topic of choice by each student to present to a peer professional group of cytology staff and medical faculty. Preparation of a referenced scientific term paper or participation in an approved research or class project pertaining to cliniccal cytology. Enroll Info: None

GENETICS/​MD GENET  677 — ADVANCED TOPICS IN GENETICS

1-3 credits.

Contents vary; consideration of subjects not included in the curriculum. Enroll Info: None

GENETICS 681 — SENIOR HONORS THESIS

2-4 credits.

Individual study for majors completing theses for Honors degrees as arranged with a faculty member. Enroll Info: None

GENETICS 682 — SENIOR HONORS THESIS

2-4 credits.

Individual study for majors completing theses for Honors degrees as arranged with a faculty member. Enroll Info: None

GENETICS 699 — SPECIAL PROBLEMS

1-3 credits.

Individual advanced work in an area of Genetics under the direct guidance of a faculty member. Enroll Info: None

GENETICS 701 — ADVANCED GENETICS

3 credits.

First semester of professional level training in genetic mechanisms and analysis as applied to genetic transmission, gene expression, forward and reverse genetics, molecular genetics, genonmics, developmental genetics, and epigenetics. Enroll Info: None

GENETICS 702 — ADVANCED GENETICS II

3 credits.

Second of semester of professional level training in genetic mechanisms and analysis as applied to genetic transmission, gene expression, forward and revese genetics, molecular genetics, genonmics, developmental genetics, and epigenetics. Enroll Info: None

GENETICS/​BIOCHEM  703 — TOPICS IN EUKARYOTIC REGULATION

2 credits.

Design and interpretation of experiments addressing molecular mechanisms of eukaryotic regulation. Enroll Info: None

GENETICS/​MD GENET  707 — GENETICS OF DEVELOPMENT

3 credits.

A research-level analysis of the current status of the investigation of processes controlling differential gene activity and cellular behavior. The major emphasis is genetic. In successive years, the focus moves from the gene to the cell to the organism. Enroll Info: None

GENETICS/​MD GENET  708 — METHODS AND LOGIC IN GENETIC ANALYSIS

3 credits.

Contemporary issues in genetic, developmental, cell, and molecular biology are addressed in a discussion format. Invited speakers give research lectures and reading material is taken from the primary literature. The discussion focuses on evaluating genetic approaches to biological problems. Enroll Info: None

GENETICS/​CRB  710 — DEVELOPMENTAL GENETICS

3 credits.

Covers a broad range of topics in animal development, with an emphasis on molecular mechanisms. Focuses on common themes, with the goal of understanding and analyzing current research in developmental biology and genetics. Enroll Info: None

GENETICS/​BOTANY/​ENTOM/​ZOOLOGY  820 — FOUNDATIONS OF EVOLUTION

2 credits.

Explore some of the most important themes and debates that have permeated evolutionary biology over the last 50 years. Read key papers related to each controversial topic, debate the pros and cons of competing viewpoints, and reflect on the relevance of the issue to contemporary evolutionary biology. Enroll Info: None

GENETICS/​BIOCHEM/​BOTANY  840 — REGULATORY MECHANISMS IN PLANT DEVELOPMENT

3 credits.

Molecular mechanisms whereby endogenous and environmental regulatory factors control development; emphasis on stimulus perception and primary events in the signal chain leading to modulated gene expression and cellular development. Enroll Info: None

GENETICS/​AN SCI/​POP HLTH  849 — GENETIC EPIDEMIOLOGY

3 credits.

This course will provide an introduction to genetic epidemiology. Topics will include a general overview of genetics and Mendelian and complex inheritance, as well as various elements of study design, including participant ascertainment; phenotype definition; biologic sample selection; genotyping, sequencing, and quality control; measurement of covariates, and choice of analytic methods. We will briefly discuss some of the original study designs and then focus on current study designs for the remainder of the class. Additional emerging topics will be briefly touched upon. Students will complete short homework assignments to enforce concepts learned during lectures, discuss journal articles, and prepare a very short grant application for the mid-term project. In the final weeks of class, students will work together to analyze data from a real genetic study, prepare tables, interpret the findings, and present their project to their peers. Enroll Info: None

GENETICS 875 — SPECIAL TOPICS

1-4 credits.

Special topics of current interest to graduate students. Enroll Info: None

GENETICS 885 — ADVANCED GENOMIC AND PROTEOMIC ANALYSIS

3 credits.

With the availability of genome sequences and high-throughput techniques, organismal physiology can now be examined on a global scale by monitoring the behavior of all genes or proteins in a single experiment. This course will present modern techniques in genomics and proteomics, with particular focus on analyzing the data generated by these techniques. Course material will cover genomic sequencing, comparative sequence analysis, phylogeny construction and phylogenomics, transcription factor motif discovery, DNA microarray analysis, techniques in mass spectrometry, proteomic screening methods, and protein-interaction network analysis. In addition to lecture time, the course includes computer lab where students get hands-on experience analyzing genomic and proteomic datasets. Students should have coursework in general statistics and intermediate or advanced genetics. Enroll Info: None

GENETICS/​MD GENET/​POP HLTH  888 — PUBLIC HEALTH GENOMICS

1 credit.

Uses knowledge gained from genetic and molecular research along with a consideration of ethical, legal, and social implications (ELSI) to prevent disease and improve the health of the population. An introduction to public health genomics through a review of fundamental principles of genetics, the use of genetic information in clinical and research settings and its implications for disease management and prevention. Gain an awareness of policies that guide public health and discuss current ethical, legal, and social implications of these policies. Enroll Info: None

GENETICS/​B M E/​B M I/​BIOCHEM/​CBE/​COMP SCI  915 — COMPUTATION AND INFORMATICS IN BIOLOGY AND MEDICINE

1 credit.

Participants and outside speakers will discuss current research in computation and informatics in biology and medicine. This seminar is required of all CIBM program trainees. Enroll Info: None

GENETICS/​AN SCI/​DY SCI  951 — SEMINAR IN ANIMAL BREEDING

0-1 credits.

Enroll Info: None

GENETICS/​AGRONOMY/​HORT  957 — SEMINAR-PLANT BREEDING

1 credit.

Graduate seminar in Plant Breeding Plant Genetics (PBPG) that requires students to give oral scientific presentations on topics chosen by the instructors and/or the student¿s thesis research. This seminar is coordinated by PBPG faculty on a rotating basis. Enroll Info: None

GENETICS 990 — RESEARCH

1-12 credits.

Independent laboratory research in preparation of a graduate thesis under supervision of a faculty member. Enroll Info: None

GENETICS 993 — SEMINAR IN GENETICS

0-1 credits.

Various aspects of genetics: Drosophila, maize, immunogenetics, developmental genetics, or other special topics. Enroll Info: None