PHM SCI 310 — DRUGS AND THEIR ACTIONS
Introduces students to the biological effects of drugs on human health. Emphasis on how drugs, especially those used in diseases of major human health significance, act in the body. Drugs that are abused also will be covered. This course is not intended for medical, nursing, pharmacy, and physician assistant students.
PHM SCI 420 — PHYSICOCHEMICAL PRINCIPLES OF DRUG FORMULATION AND DELIVERY
Applications of physicochemical principles to pharmaceutical systems.
PHM SCI 421 — INTRODUCTION TO BIOPHARMACEUTICS AND PHARMACOKINETICS
To integrate and utilize the knowledge obtained from chemistry, biochemistry, physiology, pathophysiology, and anatomy in order to develop an understanding of the fundamental principles governing biopharmaceutics, drug pharmacokinetics and drug pharmacodynamics.
PHM SCI/B M E 430 — BIOLOGICAL INTERACTIONS WITH MATERIALS
Addresses the range of materials currently being utilized for various biomedical applications, the biological systems governing biomaterial applications, analytical techniques pertinent to biomaterial evaluation, and selected major medical applications in which biomaterials play an important role.
PHM SCI 432 — PHARMACEUTICAL BIOCHEMISTRY
Chemistry of metabolic processes and products of living matter with emphasis on pharmaceutical and medicinal aspects as well as recombinant DNA technology. Laboratory experience with the chemistry of metabolic processes, products of living matter and recombinant DNA.
PHM SCI 490 — SELECTED TOPICS IN PHARMACEUTICAL SCIENCES
Specialized subject matter of current interest to undergraduate and professional students.
PHM SCI 493 — SELECTED TOPICS IN PHARMACEUTICAL SCIENCES
Specialized subject matter of current interest to graduate students.
PHM SCI/PHMCOL-M 521 — PHARMACOLOGY I
Pharmacological actions of important drugs, including drugs that affect the peripheral nervous system, the central nervous system, and the gastrointestinal tract.
PHM SCI/PHMCOL-M 522 — PHARMACOLOGY II
Pharmacological actions of important drugs, including hematopoietic, thrombolytic, antihyperlipidemic, immunopharmacologic, anticancer, anti-inflammatory, diuretic, antihypertensive, antianginal, and anti-arrhythmic agents, and agents used to treat congestive heart failure.
PHM SCI 531 — MEDICINAL CHEMISTRY I
Basic concepts in the chemistry of small molecule medicinal products. Structure activity of cholinergic, adrenergic, serotonergic and dopaminergic agents, antidepressant, antianxiety drugs, opioids, and antihistamines. Overview of drug metabolism and the clinical effects of metabolic drug interactions and genetic variability in drug metabolism genes.
PHM SCI 532 — MEDICINAL CHEMISTRY II
Chemistry of medicinal products, including antihyperlipidemics, glucocorticoids, estrogens, progestins, nonsteroidal anti-inflammatories, antitumor agents, and enzyme inhibitors.
PHM SCI 540 — DRUG DELIVERY SYSTEMS FOR PHARMACOTHERAPY
The application of physical, chemical and biological principles to the study of drug delivery using a variety of solid, solution and disperse systems as dosage forms. Rationale for therapeutic use, formulation and manufacture, and evaluation of stability and bioavailability.
PHM SCI 541 — PHARMACEUTICAL CALCULATIONS, DISPENSING AND COMPOUNDING
Introductory laboratory course in compounding and dispensing of pharmaceutical dosage forms, including sterile products. Includes practice in interpretation of prescription orders, pharmaceutical calculations, compounding procedures, physical manipulation of drugs and dosage form components, and product packaging and labeling.
PHM SCI 542 — PARENTERAL THERAPY AND NUTRITION
An introduction to parenteral therapy and nutrition focusing on the fundamental properties, calculations involved and the methods to prepare safe and reliable injectable medications for patients.
PHM SCI 558 — LABORATORY TECHNIQUES IN PHARMACOLOGY AND TOXICOLOGY
Basic laboratory techniques employed in pharmacological and toxicological research.
PHM SCI 581 — MOLECULAR AND CELLULAR PRINCIPLES IN PHARMACOLOGY
Provides an in-depth introduction to the molecular and cellular principles of pharmacology. Emphasis is on the mechanisms of drug and small molecule action in cells, with a particular focus on downstream signaling pathways, second messenger systems, protein kinase cascades, and the regulation of gene transcription.
PHM SCI 623 — PHARMACOLOGY III
Pharmacological actions and underlying basic and clinical science of antimicrobial and antiviral drugs. Pharmacology of hormones and other drugs affecting the endocrine system.
PHM SCI/M&ENVTOX/ONCOLOGY/PHMCOL-M/POP HLTH 625 — TOXICOLOGY I
Basic principles of toxicology and biochemical mechanisms of toxicity in mammalian species and man. Correlation between morphological and functional changes caused by toxicants in different organs of the body.
PHM SCI/M&ENVTOX/PATH/PHMCOL-M/POP HLTH 626 — TOXICOLOGY II
Survey of the basic methods and fundamental biochemical mechanisms of toxicity. Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented.
PHM SCI 679 — PHARMACOLOGY AND TOXICOLOGY SEMINAR
Senior student presentations of independent research or of published papers on a specific topic approved by the course coordinator. Faculty-led seminars on selected topics regarding responsible conduct of research. The course also provides a venue for career talks by Pharmacology and Toxicology alumni and guests working in a variety of professional settings - research, industry (pharmaceutical; biotech; contract research; consumer products; etc.), a variety of healthcare professions, and law.
PHM SCI 691 — SENIOR THESIS
Individual study for seniors completing theses as arranged with a faculty member.
PHM SCI 692 — SENIOR THESIS
Individual study for seniors completing theses as arranged with a faculty member.
PHM SCI 699 — ADVANCED INDEPENDENT STUDY
Directed study projects as arranged with a faculty member.
PHM SCI 750 — THE DRUG DEVELOPMENT PROCESS
Overview of the drug development process from target identification, development, preclinical studies, clinical trials to post approval monitoring. Small and Large molecules (biologics) will be covered along with a basic coverage of regulatory authorities. Brief history of drug development as well as case studies that offer insights into the development and approval process. Comprehensive overview of the process of drug development, some of the decision-making logic, the vocabulary, and the ability to communicate within the industry.
PHM SCI 751 — INTRODUCTION TO REGULATORY PRACTICE
Identifies and examines the key regulatory agencies and practices that govern the highly regulated and diverse pharmaceutical industry. Highlights current and emerging FDA and ICH regulations and guidance documents to successfully navigate meeting with the agencies and to submit required documentation for successful product development.
PHM SCI 752 — GXP (GOOD PRACTICE): WORKING IN A REGULATED ENVIRONMENT
The pharmaceutical and biopharmaceutical industries have strict documentation and production requirements. Prepares the learner to work in a regulated environment. Explains roles and responsibilities across multiple disciplines and proper documentation practices. Prepares learner for protocol, report creation and audit responses. Discusses specifications, guidances and root-cause analysis.
PHM SCI 753 — PHARMACEUTICAL ECONOMICS AND PROJECT MANAGEMENT
Provides an introduction to key terminology and lays a foundation of the critical body of knowledge project team members must master in a contemporary drug development enterprise. The latest project management theory is integrated with practical techniques and tools so that course participants learn to properly manage and schedule quality, budget, and progress objectives. Provides an overview of the economic structures, management and policy issues that drive and challenge the pharmaceutical and biotechnology industries.
PHM SCI 755 — LABORATORY AND INSTRUMENTATION METHODS
Teaches the theory and application of many common laboratory techniques and instruments used in drug discovery and development. Includes a laboratory component to teach safety and basic techniques necessary for working in a lab. Instruction begins with basic techniques and builds upon these techniques to instruct in proper sample preparation and handling for analysis using a variety of analytical instrumentation.
PHM SCI 759 — CURRENT TRENDS IN DRUG DISCOVERY AND DEVELOPMENT
Provides the experience and skill to find, read and critically analyze scientific and regulatory literature in the field of drug discovery and development.
PHM SCI 760 — SUMMATIVE RESEARCH INTERNSHIP
Summation of core coursework to a real-world project and/or internship experience. Synthesis of knowledge, skills and abilities to demonstrate aptitude for careers in respective industries.
PHM SCI/CHEM 766 — MOLECULAR RECOGNITION
Origin, nature, classification, and description of intermolecular forces. The hydrophobic effect. Molecular complexes, binding constants, and their measurements. General principles of self-assembly, molecular recognition, complex formation, host design. Supramolecular systems and their dynamics. Micelles, bilayers, vesicles, biological membranes.
PHM SCI 768 — PHARMACOKINETICS
Quantitative aspects of drug absorption, distribution, metabolism, and excretion. Philosophy and applications of pharmacokinetic modeling and its use in clinical practice.
PHM SCI 773 — MOLECULAR SOLIDS
Describes the structures, properties, formation, and transformation of molecular solids, with emphasis on pharmaceutical solids. In each area, relevant theory, experiments, and case studies are presented.
PHM SCI 775 — POLYMERIC DRUG DELIVERY
Introduction to polymers used in drug delivery, specifically polymers used in the spatial and temporal control of drugs. Discussion of basic reactions for the synthesis of polymers, biodegradable polymers, water-soluble polymer-drug conjugates, polymer assembly and nanoscale devices, and stimuli-sensitive polymers.
PHM SCI 780 — PRINCIPLES OF PHARMACEUTICAL SCIENCES
Introductory-level graduate course providing overview of the drug development process, involving drug discovery, drug action, and drug delivery. Exposes students to cutting-edge research and the chemistry, biology, physical chemistry, and engineering that underpin pharmaceutical sciences research.
PHM SCI 786 — NATURAL PRODUCT SYNTHESIS, BIOSYNTHESIS AND DRUG DISCOVERY
Synthesis and biosynthesis of natural products in drug discovery. Topics include: natural products in drug discovery; biosynthetic pathways and synthetic strategies for major natural product classes; and basic bioorganic chemistry and enzyme mechanisms in biosynthesis.
PHM SCI/B M E 801 — SEMINAR ON DEVELOPMENT OF MEDICAL DEVICES AND DRUGS
An overview of three major sectors of medical product and technology development including pharmaceuticals, medical devices and combination products. Regulatory framework, disclosure and patenting, technical design and development strategy, academia-specific development challenges will be among the major lecture topics.
PHM SCI 891 — HIGHLIGHTS AT THE CHEMISTRY-BIOLOGY INTERFACE II
Principles of key discoveries at the chemistry-biology interface. This course is required of all Chemistry-Biology Interface trainees.
PHM SCI 931 — PHARMACEUTICAL SCIENCES SEMINAR
Weekly series that provides exposure to a diverse array of research topics. Students enroll in one of three sections, corresponding to their research core (Drug Action, Drug Discovery, or Drug Delivery). Students in their 2nd year and beyond present their research progress or review literature. The course includes talks from nationally and internationally recognized scientists from academia and industry.
PHM SCI 932 — PHARMACEUTICAL SCIENCES SEMINAR
Weekly series that provides exposure to a diverse array of research topics. Students enroll in one of three sections, corresponding to their research core (Drug Action, Drug Discovery, or Drug Delivery). Students in their 2nd-year and beyond present their research progress or review literature. The course includes talks from nationally and internationally recognized scientists from academia and industry.
PHM SCI 990 — RESEARCH
Independent research and writing for graduate and students under the supervision of a faculty member.
PHM SCI 999 — ADVANCED INDEPENDENT STUDY
Directed study projects for graduate students as arranged with a faculty member.