PHM SCI 310 — DRUGS AND THEIR ACTIONS

2 credits.

Introduces students to the biological effects of drugs on human health. Emphasis on how drugs, especially those used in diseases of major human health significance, act in the body. Drugs that are abused also will be covered. This course is not intended for medical, nursing, pharmacy, and physician assistant students. Not open for cr to Nursing, Phys Asst, School of Pharm stdts

PHM SCI 401 — SURVEY OF PHARMACOLOGY

3 credits.

Pharmacological and toxicological actions and therapeutic use of important drugs. Not open for credit to School of Pharm stdts

PHM SCI 420 — INTRODUCTION TO DRUG ACTION AND DRUG DELIVERY I

4 credits.

Applications of physical principles and modern methods of analysis to pharmaceutical systems.

PHM SCI 421 — INTRODUCTION TO PHARMACODYNAMICS AND PHARMACOKINETICS

4 credits.

A conceptual introduction to the way that drugs act and are processed in vivo, including receptor theory, ligand-macromolecule binding, biopharmaceutics, drug metabolism, pharmacokinetics, and pharmacodynamics.

PHM SCI/​B M E  430 — BIOLOGICAL INTERACTIONS WITH MATERIALS

3 credits.

This course addresses the range of materials currently being utilized for various biomedical applications, the biological systems governing biomaterial applications, analytical techniques pertinent to biomaterial evaluation, and selected major medical applications in which biomaterials play an important role.

PHM SCI 432 — PHARMACEUTICAL BIOCHEMISTRY

4 credits.

Chemistry of metabolic processes and products of living matter with emphasis on pharmaceutical and medicinal aspects as well as recombinant DNA technology. Laboratory experience with the chemistry of metabolic processes, products of living matter and recombinant DNA.

PHM SCI 490 — SELECTED TOPICS IN PHARMACEUTICAL SCIENCES

1-4 credits.

PHM SCI 491 — SELECTED TOPICS IN PHARMACEUTICAL SCIENCES

1-4 credits.

PHM SCI 493 — SELECTED TOPICS IN PHARMACEUTICAL SCIENCES

1-4 credits.

PHM SCI/​PHMCOL-M  521 — PHARMACOLOGY I

3 credits.

Pharmacological actions of important drugs, including drugs that affect the peripheral nervous system, the central nervous system, and the gastrointestinal tract.

PHM SCI/​PHMCOL-M  522 — PHARMACOLOGY II

3-4 credits.

Pharmacological actions of important drugs, including hematopoietic, thrombolytic, antihyperlipidemic, immunopharmacologic, anticancer, anti-inflammatory, diuretic, antihypertensive, antianginal, and anti-arrhythmic agents, and agents used to treat congestive heart failure.

PHM SCI 531 — MEDICINAL CHEMISTRY I

2 credits.

Chemistry of medicinal products, including cholinergic, adrenergic, dopaminergic and serotonergic agents, antidepressants, sedative/hypnotics, antianxiety drugs, opioid drugs acting at histamine receptors, and inhibitors of mediator release.

PHM SCI 532 — MEDICINAL CHEMISTRY II

2 credits.

Chemistry of medicinal products, including antihyperlipidemics, glucocorticoids, estrogens, progestins, nonsteroidal anti-inflammatories, antitumor agents, and enzyme inhibitors.

PHM SCI 540 — DRUG DELIVERY SYSTEMS

4 credits.

The application of physical, chemical and biological principles to the study of drug delivery using a variety of solid, solution and disperse systems as dosage forms. Rationale for therapeutic use, formulation and manufacture, and evaluation of stability and bioavailability.

PHM SCI 541 — DRUG DELIVERY SYSTEMS LABORATORY I

3 credits.

Introductory laboratory course in compounding and dispensing of pharmaceutical dosage forms, including sterile products. Includes practice in interpretation of prescription orders, pharmaceutical calculations, compounding procedures, physical manipulation of drugs and dosage form components, and product packaging and labeling.

PHM SCI 542 — DRUG DELIVERY SYSTEMS LABORATORY II

3 credits.

Advanced extemporaneous prescription compounding and preparation of sterile products, with emphasis on physico-chemical stability and compatibility of drugs and dosage forms. Also addresses principles of appraisal, comparison, and selection of appropriate commercial brand name and generic products.

PHM SCI 558 — LABORATORY TECHNIQUES IN PHARMACOLOGY AND TOXICOLOGY

2 credits.

Basic laboratory techniques employed in pharmacological and toxicological research. S. Pharmacology Toxicology program

PHM SCI 623 — PHARMACOLOGY III

3 credits.

Pharmacological actions and underlying basic and clinical science of antimicrobial and antiviral drugs. Pharmacology of hormones and other drugs affecting the endocrine system.

PHM SCI/​M&ENVTOX/​MEDICINE/​ONCOLOGY/​PATH/​PHMCOL-M/​POP HLTH  625 — TOXICOLOGY I

3 credits.

Basic principles of toxicology and biochemical mechanisms of toxicity in mammalian species and man. Correlation between morphological and functional changes caused by toxicants in different organs of the body. Path 401 Phmcol 401 or equiv recommended

PHM SCI/​M&ENVTOX/​MEDICINE/​PATH/​PHMCOL-M/​POP HLTH  626 — TOXICOLOGY II

3 credits.

A course surveying the basic methods and fundamental biochemical mechanisms of toxicity. Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented.

PHM SCI 679 — PHARMACOLOGY AND TOXICOLOGY SEMINAR

1 credit.

Senior student presentations of independent research or of published papers on a specific topic approved by the course coordinator. Faculty-led seminars on selected topics regarding responsible conduct of research. The course also provides a venue for career talks by Pharmacology-Toxicology alumni and guests working in a variety of professional settings - research, industry(pharmaceutical; biotech; contract research; consumer products; etc.), a variety of healthcare professions, and law. S. Pharmacology Toxicology program

PHM SCI 691 — SENIOR THESIS

2 credits.

PHM SCI 692 — SENIOR THESIS

2 credits.

PHM SCI 699 — ADVANCED INDEPENDENT STUDY

3 credits.

PHM SCI 760 — GRADUATE STUDENT SEMINAR IN DRUG DELIVERY

1 credit.

Graduate seminar course for students in Drug Delivery Core of the Division of Pharmaceutical Sciences; students present original laboratory research or review literature in the setting of their fellow graduate student colleagues and the drug delivery faculty.

PHM SCI/​CHEM  766 — MOLECULAR RECOGNITION

2-3 credits.

Origin, nature, classification, and description of intermolecular forces. The hydrophobic effect. Molecular complexes, binding constants, and their measurements. General principles of self-assembly, molecular recognition, complex formation, host design. Supramolecular systems and their dynamics. Micelles, bilayers, vesicles, biological membranes.

PHM SCI 768 — PHARMACOKINETICS

3 credits.

Quantitative aspects of drug absorption, distribution, metabolism, and excretion. Philosophy and applications of pharmacokinetic modeling and its use in clinical practice.

PHM SCI 773 — MOLECULAR SOLIDS

2 credits.

Describes the structures, properties, formation, and transformation of molecular solids, with emphasis on pharmaceutical solids. In each area, relevant theory, experiments, and case studies are presented.

PHM SCI 775 — POLYMERIC DRUG DELIVERY

2 credits.

Introduction to polymers used in drug delivery, specifically polymers used in the spatial and temporal control of drugs. Discussion of basic reactions for the synthesis of polymers, biodegradable polymers, water-soluble polymer-drug conjugates, polymer assembly and nanoscale devices, and stimuli-sensitive polymers.

PHM SCI 780 — PRINCIPLES OF PHARMACEUTICAL SCIENCES

3 credits.

Introductory-level graduate course providing overview of the drug development process, involving drug discovery, drug action, and drug delivery. Exposes students to cutting-edge research and the chemistry, biology, physical chemistry, and engineering that underpin pharmaceutical sciences research.

PHM SCI 786 — NATURAL PRODUCT SYNTHESIS, BIOSYNTHESIS AND DRUG DISCOVERY

3 credits.

Synthesis and biosynthesis of natural products in drug discovery. Topics include: natural products in drug discovery; biosynthetic pathways and synthetic strategies for major natural product classes; and basic bioorganic chemistry and enzyme mechanisms in biosynthesis.

PHM SCI/​B M E  801 — SEMINAR ON DEVELOPMENT OF MEDICAL DEVICES AND DRUGS

1 credit.

This course will give an overview of three major sectors of medical product and technology development including pharmaceuticals, medical devices and combination products. Regulatory framework, disclosure and patenting, technical design and development strategy, academia-specific development challenges will be among the major lecture topics.

PHM SCI 890 — HIGHLIGHTS AT THE CHEMISTRY-BIOLOGY INTERFACE I

1 credit.

Principles of key discoveries at the chemistry-biology interface. This course is required of all Chemistry-Biology Interface trainees.

PHM SCI 891 — HIGHLIGHTS AT THE CHEMISTRY-BIOLOGY INTERFACE II

1 credit.

Principles of key discoveries at the chemistry-biology interface. This course is required of all Chemistry-Biology Interface trainees.

PHM SCI 931 — PHARMACEUTICAL SCIENCES SEMINAR

1 credit.

PHM SCI 932 — PHARMACEUTICAL SCIENCES SEMINAR

1 credit.

Continuation of 931.

PHM SCI 990 — RESEARCH

1-12 credits.

PHM SCI 999 — ADVANCED INDEPENDENT STUDY

1-12 credits.